In the following list, the dates in parentheses are the earliest approved use of the drug.

Aldehydes

Main article: Aldehydes

Paraldehyde (1882). One of the earliest anticonvulsants. Still used to treat status epilepticus, particularly where there are no resuscitation facilities.

Aromatic allylic alcohols

Stiripentol (2001 - limited availability). Indicated for the treatment of severe myoclonic epilepsy in infancy (SMEI).

Barbiturates

Main article: Barbiturates

Barbiturates are drugs that act as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. The following are classified as anticonvulsants:

Phenobarbital (1912). See also the related drug primidone.
Methylphenobarbital (1935). Known as mephobarbital in the US. No longer marketed in the UK
Metharbital (1952). No longer marketed in the UK or US.
Barbexaclone (1982). Only available in some European countries.

Phenobarbital was the main anticonvulsant from 1912 till the development of phenytoin in 1938. Today, phenobarbital is rarely used to treat epilepsy in new patients since there are other effective drugs that are less sedating. Phenobarbital sodium injection can be used to stop acute convulsions or status epilepticus, but a benzodiazepine such as lorazepam, diazepam or midazolam is usually tried first. Other barbiturates only have an anticonvulsant effect at anaesthetic doses.

Benzodiazepines

Main article: Benzodiazepines

The benzodiazepines are a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and muscle relaxant properties. The relative strength of each of these properties in any given benzodiazepine varies greatly and influences the indications for which it is prescribed. Long-term use can be problematic due to the development of tolerance and dependency. Of the many drugs in this class, only a few are used to treat epilepsy:

Clobazam (1979). Notably used on a short-term basis around menstruation in women with catamenial epilepsy.
Clonazepam (1974).
Clorazepate (1972).

The following benzodiazepines are used to treat status epilepticus:

Diazepam (1963). Can be given rectally by trained care-givers.
Midazolam (N/A). Increasingly being used as an alternative to diazepam. This water-soluble drug is squirted into the side of the mouth but not swallowed. It is rapidly absorbed by the buccal mucosa.
Lorazepam (1972). Given by injection in hospital.

Bromides

Main article: Bromides

Potassium bromide (1857). The earliest effective treatment for epilepsy. There would not be a better drug for epilepsy until phenobarbital in 1912. It is still used as an anticonvulsant for dogs and cats.

Carbamates

Main article: Carbamates

Felbamate (1993). This effective anticonvulsant has had its usage severely restricted due to rare but life-threatening side effects.

Carboxamides

Main article: Carboxamides

The following are carboxamides:

Carbamazepine (1963). A popular anticonvulsant that is available in generic formulations.
Oxcarbazepine (1990). A derivative of carbamazepine that has similar efficacy but is better tolerated.

Fatty acids

Main article: Fatty acids

The following are fatty-acids:

The valproates — valproic acid, sodium valproate, and divalproex sodium (1967).
Vigabatrin (1989).
Progabide
Tiagabine (1996).

Vigabatrin and progabide are also analogs of GABA.

Fructose derivatives

Main article: Fructose

Topiramate (1995).

Gaba analogs

Gabapentin (1993).
Pregabalin (2004).

Hydantoins

Main article: Hydantoins

The following are hydantoins:

Ethotoin (1957).
Phenytoin (1938).
Mephenytoin
Fosphenytoin (1996).

Oxazolidinediones

Main article: Oxazolidinediones

The following are oxazolidinediones:

Paramethadione
Trimethadione (1946).
Ethadione

Propionates

Main article: Propionates

Beclamide

Pyrimidinediones

Main article: Pyrimidinediones

Primidone (1952).

Pyrrolidines

Main article: Pyrrolidines

Brivaracetam
Levetiracetam (1999).
Seletracetam

Succinimides

Main article: Succinimides

The following are succinimides:

Ethosuximide (1955).
Phensuximide
Mesuximide

Sulfonamides

Main article: Sulfonamides

Acetazolamide (1953).
Sulthiame
Methazolamide
Zonisamide (2000).

Triazines

Main article: Triazines

Lamotrigine (1990).

Ureas

Main article: Ureas

Pheneturide
Phenacemide

Valproylamides (amide derivatives of valproate)

Main article: Amides

Valpromide
Valnoctamide